Tag Archives: quinine

The March 3rd issue summary podcast is presented by Dr. Kirsten Patrick, deputy editor, and Dr. Domhnall MacAuley, associate editor.

Dr. Patrick and Dr. MacAuley discuss the following:

  • Seasonal variation of nocturnal leg cramps
  • Concerns over the use of quinine to treat leg cramps
  • Quality indicators of pharmacotherapy
  • Dangers of trimethoprim-sulfamethoxazole co-prescribed with spironolactone
  • IV immunoglobulin as therapy
  • Human myiasis in Canada
  • Use of primary care EMR data for research
  • What's happening on CMAJ Blogs

And more...


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CMAJ is now offering author interviews as part of our regular podcasts. This week:

Audio interview with Dr. David Hogan, geriatric medicine specialist at the University of Calgary. Quinine sulfate is widely used off label to treat nocturnal leg cramps in Canada. Although modestly effective for this indication, the drug has many potential moderate and severe adverse effects.

Interview with Dr. Scott Garrison, associate professor in the Department of Family Medicine at the University of Alberta, and lead author of the prospective cohort study. This time-series analysis used data from BC for new quinine prescriptions, as well as search data from Google Trends. The authors found that nocturnal leg cramps display striking seasonal variability, with incidence highest in summer and lowest in winter.